{
  "id": 3053,
  "label": "integumentary system cancer",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0000653",
  "properties": {
    "xrefs": [
      "DOID:0060122"
    ],
    "synonyms": [
      "cancer of integumental system",
      "integumental system cancer",
      "malignant integumental system neoplasm",
      "malignant neoplasm of integumental system"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      }
    ],
    "definition": "A malignant neoplasm involving the integumental system"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 7,
  "parents": [
    {
      "id": 4198,
      "label": "integumentary system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:16",
          "EFO:0010285",
          "MEDGEN:712400",
          "SCTID:128598002",
          "UMLS:C1290011"
        ],
        "synonyms": [
          "disease of integumental system",
          "disease or disorder of integumental system",
          "disorder of integumental system",
          "integumental system disease",
          "integumental system disease or disorder",
          "integumentary disease",
          "disorder of integument"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A disease involving the integumental system."
      },
      "child_count": 36,
      "reference_id": "MONDO:0002051"
    },
    {
      "id": 6733,
      "label": "cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050686",
          "DOID:0050687",
          "DOID:162",
          "ICD9:195.8",
          "ICD9:199",
          "ICD9:199.1",
          "ICDO:8000/3",
          "MEDGEN:14297",
          "NCIT:C9305",
          "ONCOTREE:MT",
          "SCTID:363346000",
          "UMLS:C0006826",
          "birnlex:406"
        ],
        "synonyms": [
          "CA",
          "cancer",
          "cell type cancer",
          "malignancy",
          "malignant growth",
          "malignant neoplasm",
          "malignant neoplasm (disease)",
          "malignant neoplastic disease",
          "malignant tumor",
          "malignant tumour",
          "neoplasm (disease), malignant",
          "neoplasm, malignant",
          "MT"
        ],
        "definition": "A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas (adenocarcinomas or squamous cell carcinomas), Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas."
      },
      "child_count": 33,
      "reference_id": "MONDO:0004992"
    }
  ],
  "children": [
    {
      "id": 4848,
      "label": "bartholin gland carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3053,
        6931,
        20353
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3999",
          "DOID:60003",
          "EFO:1000103",
          "GARD:0023257",
          "HP:0030419",
          "MEDGEN:83888",
          "NCIT:C9055",
          "SCTID:276876007",
          "UMLS:C0349561"
        ],
        "synonyms": [
          "Bartholin gland cancer",
          "Bartholin gland carcinoma (disease)",
          "Bartholin's gland cancer",
          "Bartholin's gland carcinoma",
          "bartholin gland carcinoma",
          "carcinoma of Bartholin's gland",
          "carcinoma of major vestibular gland",
          "carcinoma of the Bartholin's gland",
          "major vestibular gland carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from the Bartholin gland. It usually affects women over fifty and presents with enlargement of the Bartholin gland. Various histologic subtypes have been identified and include adenocarcinoma, squamous cell carcinoma, adenoid cystic carcinoma, adenosquamous carcinoma, transitional cell carcinoma, and small cell carcinoma."
      },
      "child_count": 12,
      "reference_id": "MONDO:0002829"
    },
    {
      "id": 4907,
      "label": "skin cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3053,
        4599
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4159",
          "ICD10CM:C43-C44",
          "ICD9:173.8",
          "ICD9:173.9",
          "MEDGEN:40101",
          "NCIT:C2920",
          "SCTID:372130007",
          "UMLS:C0007114",
          "icd11.foundation:1706880799"
        ],
        "synonyms": [
          "cancer of zone of skin",
          "malignant neoplasm of skin",
          "malignant neoplasm of the skin",
          "malignant neoplasm of zone of skin",
          "malignant skin neoplasm",
          "malignant skin tumor",
          "malignant skin tumour",
          "malignant tumor of skin",
          "malignant tumor of the skin",
          "malignant tumour of skin",
          "malignant tumour of the skin",
          "malignant zone of skin neoplasm",
          "melanoma and non-melanoma skin cancer",
          "skin cancer",
          "skin cancer, Including melanoma",
          "skin neoplasm, malignant",
          "zone of skin cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the zone of skin"
      },
      "child_count": 26,
      "reference_id": "MONDO:0002898"
    },
    {
      "id": 5808,
      "label": "nipple carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3053,
        4562,
        6730
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6629",
          "MEDGEN:233756",
          "NCIT:C28432",
          "UMLS:C1334966"
        ],
        "synonyms": [
          "carcinoma of nipple",
          "nipple cancer",
          "nipple carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the nipple"
      },
      "child_count": 6,
      "reference_id": "MONDO:0003950"
    },
    {
      "id": 6729,
      "label": "breast adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3053,
        6712,
        6730
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3458",
          "EFO:0000304",
          "MEDGEN:167809",
          "NCIT:C5214",
          "UMLS:C0858252"
        ],
        "synonyms": [
          "adenocarcinoma of breast",
          "adenocarcinoma of the breast",
          "breast adenocarcinoma",
          "mammary adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A carcinoma that arises from glandular epithelial cells of the breast"
      },
      "child_count": 39,
      "reference_id": "MONDO:0004988"
    },
    {
      "id": 7672,
      "label": "atypical lobular breast hyperplasia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3053,
        4565,
        6775
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000100",
          "ICD9:610.8",
          "MEDGEN:277968",
          "NCIT:C4730",
          "SCTID:450697004",
          "UMLS:C1368920"
        ],
        "synonyms": [
          "ALH",
          "atypical breast lobular hyperplasia",
          "atypical lobular breast hyperplasia",
          "atypical lobular hyperplasia",
          "atypical lobular hyperplasia of breast",
          "atypical lobular hyperplasia of the breast"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "Lobular neoplasia characterized by lobular epithelial proliferation that does not completely fill the lobular unit of the breast."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006098"
    },
    {
      "id": 7685,
      "label": "breast diffuse large B-cell lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3028,
        3053,
        5548,
        18833
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000144",
          "GARD:0024299",
          "MEDGEN:267764",
          "NCIT:C40375",
          "UMLS:C1511306"
        ],
        "synonyms": [
          "breast DLBCL",
          "breast diffuse large B-cell lymphoma",
          "diffuse large B-cell lymphoma of breast"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A diffuse large B-cell lymphoma that arises from the breast. It is the most common type of primary breast lymphoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006117"
    },
    {
      "id": 13008,
      "label": "dermatofibrosarcoma protuberans",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3053,
        6886
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3507",
          "GARD:0009569",
          "ICDO:8832/3",
          "MEDGEN:811326",
          "MESH:D018223",
          "MedDRA:10057070",
          "NCIT:C4683",
          "OMIM:607907",
          "ONCOTREE:DFSP",
          "Orphanet:31112",
          "SCTID:276799004",
          "UMLS:C3693482",
          "icd11.foundation:1579898301"
        ],
        "synonyms": [
          "DFSP",
          "dermatofibrosarcoma",
          "dermatofibrosarcoma protuberans",
          "familial dermatofibrosarcoma protuberans (subtype)",
          "giant cell fibroblastoma",
          "metastatic dermatofibrosarcoma protuberans (subtype)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "Dermatofibrosarcoma protuberans (DFSP) is a rare infiltrating soft tissue sarcoma, generally of low grade malignancy, arising from the dermis of the skin and characteristically associated with a specific chromosomal translocation t(17;22)."
      },
      "child_count": 2,
      "reference_id": "MONDO:0011934"
    }
  ],
  "roots": [
    {
      "id": 4198,
      "label": "integumentary system disorder"
    },
    {
      "id": 6733,
      "label": "cancer"
    }
  ]
}