{
  "id": 2876,
  "label": "malignant Leydig cell tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0000377",
  "properties": {
    "xrefs": [
      "DOID:0050616",
      "ICDO:8650/3",
      "MEDGEN:83143",
      "NCIT:C4213",
      "UMLS:C0334410"
    ],
    "synonyms": [
      "Leydig cell cancer",
      "Leydig cell tumor, malignant",
      "cancer of Leydig cell",
      "malignant Leydig cell neoplasm",
      "malignant interstitial cell neoplasm",
      "malignant neoplasm of Leydig cell",
      "malignant interstitial cell tumor",
      "malignant interstitial cell tumour"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      }
    ],
    "definition": "A Leydig cell tumor characterized by large tumor size, the presence of cytologic atypia, increased mitotic activity, necrosis, and vascular invasion. Approximately 10% of the testicular Leydig cell tumors show malignant characteristics and metastasize. Leydig cell tumors of the ovary follow a benign clinical course."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 4279,
      "label": "reproductive system cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        7638
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:193",
          "MEDGEN:233668",
          "NCIT:C36076",
          "UMLS:C1334618"
        ],
        "synonyms": [
          "reproductive tumor",
          "reproductive tumour",
          "cancer of reproductive organ",
          "cancer of reproductive system",
          "malignant neoplasm of reproductive organ",
          "malignant neoplasm of reproductive system",
          "malignant reproductive organ neoplasm",
          "malignant reproductive system neoplasm",
          "reproductive organ cancer",
          "reproductive system cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the reproductive organ"
      },
      "child_count": 16,
      "reference_id": "MONDO:0002149"
    },
    {
      "id": 7810,
      "label": "Leydig cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7639
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2696",
          "EFO:1000321",
          "ICDO:8650/1",
          "MEDGEN:9747",
          "MESH:D007984",
          "NCIT:C3188",
          "UMLS:C0023601"
        ],
        "synonyms": [
          "Leydig cell neoplasm",
          "Leydig cell tumor",
          "interstitial cell neoplasm",
          "interstitial cell tumor",
          "interstitial cell tumour",
          "Leydig cell tumor, undetermined"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A sex cord-stromal tumor occurring in the testis and rarely in the ovary. It is predominantly or completely composed of Leydig cells which may contain crystals of Reinke. In males it usually presents as a painless testicular enlargement and it may be associated with gynecomastia and decreased libido. The majority of the cases have a benign clinical course. Approximately 10% of the cases have a malignant clinical course and metastasize. In females it may be associated with androgenic manifestations and it follows a benign clinical course."
      },
      "child_count": 3,
      "reference_id": "MONDO:0006266"
    }
  ],
  "children": [
    {
      "id": 5617,
      "label": "malignant testicular Leydig cell tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2876,
        5101,
        7111
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6021",
          "GARD:0023641",
          "MEDGEN:271769",
          "NCIT:C39942",
          "UMLS:C1515288"
        ],
        "synonyms": [
          "testicular Leydig cell tumor, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A Leydig cell tumor characterized by a large size, cellular atypia, high mitotic activity, vascular invasion and necrotic changes. The prognosis is usually poor."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003737"
    }
  ],
  "roots": [
    {
      "id": 4279,
      "label": "reproductive system cancer"
    },
    {
      "id": 7810,
      "label": "Leydig cell tumor"
    }
  ]
}