{
  "id": 17497,
  "label": "onchocerciasis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0017137",
  "properties": {
    "xrefs": [
      "DOID:11678",
      "EFO:0007402",
      "GARD:0007252",
      "ICD10CM:B73",
      "ICD10WHO:B73",
      "ICD9:125.3",
      "MEDGEN:14477",
      "MESH:D009855",
      "MedDRA:10030314",
      "MedDRA:10039202",
      "NCIT:C34861",
      "Orphanet:2737",
      "SCTID:38539003",
      "UMLS:C0029001",
      "icd11.foundation:106136071"
    ],
    "synonyms": [
      "Onchocerca volvulus infection",
      "infection by Onchocerca volvulus",
      "onchocerciasis",
      "River blindness",
      "Robles' disease",
      "infection caused by Onchocerca volvulus",
      "onchocercosis"
    ],
    "definition": "Onchocerciasis is a form of filariasis, caused by the parasitic worm Onchocerca volvulus, transmitted by the black fly. The infection can either be asymptomatic or manifest as an ocular disease (river blindness) with itchy eyes, erythema, photophobia, onchodermatitis or onchocercal skin disease (classified into acute papular, chronic papular, lichenified, atrophic, and depigmentated) and onchocercomas (over bony prominences). Other classic clinical manifestations are ichthyosis-like lesions (''lizard skin'') and ''hanging groin'', which may be associated with lymphadenopathy."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 7539,
      "label": "Rhabditida infectious disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7478
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0008203",
          "MEDGEN:57950",
          "MESH:D017196",
          "UMLS:C0162631"
        ],
        "synonyms": [
          "Rhabditida infection",
          "Rhabditida infections",
          "infection, Rhabditida",
          "infections, Rhabditida"
        ],
        "definition": "Infections with nematodes of the order rhabditida."
      },
      "child_count": 12,
      "reference_id": "MONDO:0005943"
    },
    {
      "id": 16705,
      "label": "filariasis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6448
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1080",
          "GARD:0018757",
          "ICD10CM:B74",
          "ICD10WHO:B74",
          "ICD9:125.9",
          "MEDGEN:4706",
          "MESH:D005368",
          "MedDRA:10016674",
          "NCIT:C34611",
          "NORD:1148",
          "Orphanet:2034",
          "SCTID:105706003",
          "UMLS:C0016085",
          "icd11.foundation:1975325075"
        ],
        "definition": "A parasitic disease caused by tissue-invasive, vector-borne nematodes which can be found anywhere in the human body and that are transmitted to humans through the bite of an infected mosquito or fly or by consumption of unsafe drinking water and which, depending on the subtype can manifest with lymphedema, dermatitis, subcutaneous edema and eye involvement. The disorder is a major public health problem in many tropical and subtropical countries. Six subtypes have been described in the literature: lymphatic filariasis, onchocerciasis, loiasis, mansonelliasis, dirofilariasis and dracunculiasis caused by Wuchereria bancrofti and filarioidea of the genus Brugia; Onchocerca volvulus; Loa loa; Mansonella; Dirofilaria; and Dracunculus medinensis, respectively. Tropical eosinophilia is considered a frequent manifestation."
      },
      "child_count": 7,
      "reference_id": "MONDO:0016075"
    },
    {
      "id": 23869,
      "label": "vector-borne disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7200
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:738484",
          "MESH:D000079426",
          "UMLS:C1640363"
        ],
        "synonyms": [
          "vector-borne infection",
          "vector-borne infectious disease"
        ],
        "definition": "An infectious disease where a pathogen is carried and transmitted by another organism that acts as disease vector."
      },
      "child_count": 49,
      "reference_id": "MONDO:0100120"
    }
  ],
  "children": [
    {
      "id": 7484,
      "label": "ocular onchocerciasis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17497,
        20247
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0007398",
          "GARD:0024250",
          "MEDGEN:45196",
          "MESH:D015827",
          "NCIT:C34862",
          "SCTID:240842000",
          "UMLS:C0029002"
        ],
        "synonyms": [
          "eyeball of camera-type eye onchocerciasis",
          "onchocerciasis of eyeball of camera-type eye"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Onchocerciasis affecting the eye."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005878"
    }
  ],
  "roots": [
    {
      "id": 7539,
      "label": "Rhabditida infectious disease"
    },
    {
      "id": 16705,
      "label": "filariasis"
    },
    {
      "id": 23869,
      "label": "vector-borne disease"
    }
  ]
}