{
  "id": 17060,
  "label": "loiasis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016566",
  "properties": {
    "xrefs": [
      "DOID:13523",
      "EFO:1000729",
      "GARD:0003283",
      "ICD10CM:B74.3",
      "ICD9:125.2",
      "MEDGEN:6132",
      "MESH:D008118",
      "MedDRA:10024797",
      "NCIT:C34784",
      "Orphanet:2404",
      "SCTID:44250009",
      "UMLS:C0023968",
      "icd11.foundation:709184369"
    ],
    "synonyms": [
      "African eye worm",
      "Loa loa filariasis"
    ],
    "definition": "Loiasis is a form of filariasis (see this term), caused by the parasitic worm Loa loa, endemic to the forest and savannah regions of Central and Western Africa. Loiasis may either be asymptomatic or manifest as a large, transient area of localized, non-erythematous subcutaneous edema (Calabar swellings), adult worm migration through the sub-conjunctiva (''African eye worm'') and pruritus. Generalized itching, hives, muscle pains, arthralgias, fatigue, and adult worms visibly migrating under the surface of the skin may be observed. Severe complications such as encephalopathy have been reported in highly infected individuals receiving ivermectin during mass drug administration programs for the control of onchocerciasis and lymphatic filariasis."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 16705,
      "label": "filariasis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6448
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1080",
          "GARD:0018757",
          "ICD10CM:B74",
          "ICD10WHO:B74",
          "ICD9:125.9",
          "MEDGEN:4706",
          "MESH:D005368",
          "MedDRA:10016674",
          "NCIT:C34611",
          "NORD:1148",
          "Orphanet:2034",
          "SCTID:105706003",
          "UMLS:C0016085",
          "icd11.foundation:1975325075"
        ],
        "definition": "A parasitic disease caused by tissue-invasive, vector-borne nematodes which can be found anywhere in the human body and that are transmitted to humans through the bite of an infected mosquito or fly or by consumption of unsafe drinking water and which, depending on the subtype can manifest with lymphedema, dermatitis, subcutaneous edema and eye involvement. The disorder is a major public health problem in many tropical and subtropical countries. Six subtypes have been described in the literature: lymphatic filariasis, onchocerciasis, loiasis, mansonelliasis, dirofilariasis and dracunculiasis caused by Wuchereria bancrofti and filarioidea of the genus Brugia; Onchocerca volvulus; Loa loa; Mansonella; Dirofilaria; and Dracunculus medinensis, respectively. Tropical eosinophilia is considered a frequent manifestation."
      },
      "child_count": 7,
      "reference_id": "MONDO:0016075"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 16705,
      "label": "filariasis"
    }
  ]
}