{ "id": 12183, "label": "cerebrovascular disorder", "model": { "label": "Mondo Disease Ontology (MONDO)", "source": 0 }, "type_id": 0, "reference_id": "MONDO:0011057", "properties": { "xrefs": [ "DOID:6713", "EFO:0003763", "ICD10CM:I60-I69", "ICD9:430-438", "ICD9:434.91", "ICD9:437.8", "ICD9:437.9", "MEDGEN:858", "MESH:D002561", "NCIT:C2938", "SCTID:62914000", "UMLS:C0007820", "icd11.foundation:843843448" ], "synonyms": [ "cerebrovascular disease", "cerebrovascular disorder", "CVA", "CVA (cerebral vascular accident)", "cerebral infarction", "cerebrovascular accident", "stroke" ], "categories": [ { "ref": "MONDO:0004995", "name": "cardiovascular disorder" }, { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "A disorder resulting from inadequate blood flow in the vessels that supply the brain. Representative examples include cerebrovascular ischemia, cerebral embolism, and cerebral infarction." }, "isLeaf": false, "isRoot": false, "child_count": 24, "parents": [ { "id": 7209, "label": "brain disorder", "isLeaf": false, "isRoot": false, "parents": [ 4657 ], "type_id": 0, "properties": { "xrefs": [ "DOID:936", "EFO:0005774", "ICD9:348.3", "ICD9:348.30", "ICD9:348.8", "ICD9:348.9", "MEDGEN:14214", "MESH:D001927", "NCIT:C96413", "SCTID:81308009", "UMLS:C0006111" ], "synonyms": [ "brain disease", "brain disease or disorder", "disease of brain", "disease or disorder of brain", "disorder of brain", "encephalopathy" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "A disease affecting the brain or part of the brain." }, "child_count": 71, "reference_id": "MONDO:0005560" }, { "id": 23165, "label": "neurovascular disorder", "isLeaf": false, "isRoot": false, "parents": [ 6799, 7065 ], "type_id": 0, "properties": { "xrefs": [ "MEDGEN:857738", "NCIT:C117007", "UMLS:C3898144" ], "synonyms": [ "disease of nervous system vasculature", "nervous system disorder of vasculature", "neurovascular disorder", "vasculature nervous system disorder" ], "categories": [ { "ref": "MONDO:0004995", "name": "cardiovascular disorder" }, { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "A disorder of the nervous system related to a vascular etiology." }, "child_count": 58, "reference_id": "MONDO:0043218" } ], "children": [ { "id": 3512, "label": "cerebral arteritis", "isLeaf": true, "isRoot": false, "parents": [ 5281, 12183, 23218 ], "type_id": 0, "properties": { "xrefs": [ "DOID:11390", "GARD:0022913", "ICD9:437.4", "MEDGEN:507535", "SCTID:28366008", "UMLS:C0007773" ], "synonyms": [ "cerebral artery inflammation", "inflammation of cerebral artery" ], "categories": [ { "ref": "MONDO:0004995", "name": "cardiovascular disorder" }, { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "An inflammatory disease involving a pathogenic inflammatory response in the cerebral artery." }, "child_count": 0, "reference_id": "MONDO:0001277" }, { "id": 4914, "label": "intracranial thrombosis", "isLeaf": false, "isRoot": false, "parents": [ 3150, 12183 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4193", "ICD9:434.0", "ICD9:434.00", "MEDGEN:199820", "MESH:D020767", "SCTID:71444005", "UMLS:C0752143" ], "categories": [ { "ref": "MONDO:0004995", "name": "cardiovascular disorder" }, { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "Formation or presence of a blood clot (thrombus) in a blood vessel within the skull. Intracranial thrombosis can lead to thrombotic occlusions and brain infarction. The majority of the thrombotic occlusions are associated with atherosclerosis." }, "child_count": 4, "reference_id": "MONDO:0002907" }, { "id": 5599, "label": "occlusion precerebral artery", "isLeaf": false, "isRoot": false, "parents": [ 12183 ], "type_id": 0, "properties": { "xrefs": [ "DOID:5976", "EFO:0009677", "ICD9:433", "ICD9:433.3", "ICD9:433.80", "ICD9:433.81", "ICD9:433.9", "MEDGEN:539069", "SCTID:28790007", "UMLS:C0265090" ], "categories": [ { "ref": "MONDO:0004995", "name": "cardiovascular disorder" }, { "ref": "MONDO:0005071", "name": "nervous system disorder" } ] }, "child_count": 3, "reference_id": "MONDO:0003718" }, { "id": 6434, "label": "vascular dementia", "isLeaf": false, "isRoot": false, "parents": [ 3823, 12183 ], "type_id": 0, "properties": { "xrefs": [ "DOID:8725", "EFO:0004718", "ICD10CM:F01", "ICD10CM:F01.5", "ICD10WHO:F01", "ICD9:290.4", "MEDGEN:41447", "MESH:D015140", "NCIT:C34525", "SCTID:429998004", "UMLS:C0011269", "icd11.foundation:1365258270" ], "synonyms": [ "vascular dementia", "multi infarct dementia", "multifocal dementia" ], "categories": [ { "ref": "MONDO:0004995", "name": "cardiovascular disorder" }, { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "A degenerative vascular disorder affecting the brain. It is caused by the blockage of the blood supply to the brain. It is manifested with decline of memory and cognitive functions." }, "child_count": 2, "reference_id": "MONDO:0004648" }, { "id": 6825, "label": "stroke disorder", "isLeaf": false, "isRoot": false, "parents": [ 12183 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0051061", "EFO:0000712", "HP:0001297", "MEDGEN:52522", "MESH:D020521", "NCIT:C3390", "SCTID:230690007", "UMLS:C0038454", "birnlex:12783" ], "synonyms": [ "CVA", "CVA, cerebrovascular accident", "cerebrovascular accident", "cerebrovascular accident, (CVA)", "stroke", "stroke syndrome", "syndrome, stroke", "undetermined stroke", "cerebral infarction" ], "categories": [ { "ref": "MONDO:0004995", "name": "cardiovascular disorder" }, { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "A sudden loss of neurological function secondary to hemorrhage or ischemia in the brain parenchyma due to a vascular event." }, "child_count": 4, "reference_id": "MONDO:0005098" }, { "id": 6910, "label": "internal carotid artery stenosis", "isLeaf": true, "isRoot": false, "parents": [ 12183 ], "type_id": 0, "properties": { "xrefs": [ "EFO:0002615", "ICD9:433.10", "MEDGEN:87405", "SCTID:233964008", "UMLS:C0340569", "Wikipedia:Carotid_artery_stenosis" ], "categories": [ { "ref": "MONDO:0004995", "name": "cardiovascular disorder" }, { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "Carotid stenosis is a narrowing or constriction of the inner surface (lumen) of the carotid artery, usually caused by atherosclerosis. The internal carotid artery supplies the brain. Plaque often builds up at that division, and causes a narrowing (stenosis). Pieces of plaque can break off and block the small arteries above in the brain, which causes a stroke. Plaque can also build up at the origin of the carotid artery at the aorta." }, "child_count": 0, "reference_id": "MONDO:0005189" }, { "id": 6968, "label": "carotid artery disorder", "isLeaf": false, "isRoot": false, "parents": [ 2933, 12183 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3407", "EFO:0003781", "ICD9:447.9", "MEDGEN:2892", "MESH:D002340", "NCIT:C84476", "SCTID:371160000", "UMLS:C0007273" ], "synonyms": [ "carotid artery disorder", "carotid artery segment disease", "carotid artery segment disease or disorder", "disease of carotid artery segment", "disease or disorder of carotid artery segment", "disorder of carotid artery segment" ], "categories": [ { "ref": "MONDO:0004995", "name": "cardiovascular disorder" }, { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "A disease involving the carotid artery segment." }, "child_count": 12, "reference_id": "MONDO:0005269" }, { "id": 6993, "label": "brain ischemia", "isLeaf": false, "isRoot": false, "parents": [ 6784, 12183 ], "type_id": 0, "properties": { "xrefs": [ "DOID:2316", "ICD9:348.89", "MEDGEN:182975", "MESH:D002545", "NCIT:C78394", "SCTID:389100007", "UMLS:C0917798" ], "synonyms": [ "brain ischaemic disease", "brain ischemia", "brain ischemic disease", "cerebrovascular ischemia", "ischaemic disease of brain", "ischemia cerebrovascular", "ischemic disease of brain" ], "categories": [ { "ref": "MONDO:0004995", "name": "cardiovascular disorder" }, { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "Diminished or absent blood supply to the brain caused by obstruction (thrombosis or embolism) of an artery resulting in neurologic damage." }, "child_count": 6, "reference_id": "MONDO:0005299" }, { "id": 7072, "label": "brain infarction", "isLeaf": false, "isRoot": false, "parents": [ 12183 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3454", "EFO:0004277", "MEDGEN:148426", "MESH:D020520", "UMLS:C0751955" ], "categories": [ { "ref": "MONDO:0004995", "name": "cardiovascular disorder" }, { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "Tissue necrosis in any area of the brain, including the cerebral hemispheres, the cerebellum, and the brain stem. Brain infarction is the result of a cascade of events initiated by inadequate blood flow through the brain that is followed by hypoxia and hypoglycemia in brain tissue. Damage may be temporary, permanent, selective or pan-necrosis." }, "child_count": 3, "reference_id": "MONDO:0005394" }, { "id": 7260, "label": "cerebral amyloid angiopathy", "isLeaf": false, "isRoot": false, "parents": [ 12183, 18631, 24270 ], "type_id": 0, "properties": { "xrefs": [ "DOID:9246", "EFO:0006790", "GARD:0010266", "ICD10CM:I68.0", "ICD9:277.39", "MEDGEN:267610", "MESH:D016657", "NCIT:C84625", "Orphanet:85458", "SCTID:230724001", "UMLS:C1510489" ], "synonyms": [ "HCHWA", "dutch hereditary cerebral amyloid angiopathy", "hereditary cerebral haemorrhage with amyloidosis - Dutch type", "hereditary cerebral hemorrhage with amyloidosis - Dutch type", "CAA, familial", "cerebral amyloid angiopathy, familial", "cerebral amyloid angiopathy, genetic" ], "categories": [ { "ref": "MONDO:0004995", "name": "cardiovascular disorder" }, { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "Hereditary cerebral hemorrhage with amyloidosis (HCHWA) describes a group of rare familial central nervous system disorders characterized by amyloid deposition in the cerebral blood vessels leading to hemorrhagic and non-hemorrhagic strokes, focal neurological deficits, and progressive cognitive decline eventually leading to dementia." }, "child_count": 12, "reference_id": "MONDO:0005620" }, { "id": 7261, "label": "vascular brain injury", "isLeaf": true, "isRoot": false, "parents": [ 12183, 23219 ], "type_id": 0, "properties": { "xrefs": [ "EFO:0006791", "MESH:D020214" ], "synonyms": [ "Brain Vascular injury", "Brain Vascular trauma", "Brain injury, Vascular", "Vascular Brain Injuries", "Vascular Brain injury", "Vascular Traumas, Brain", "Vascular injury, Brain", "Vascular trauma, Brain", "injury, Brain Vascular", "injury, Vascular Brain", "injury, Vascular, Brain", "trauma, Brain Vascular", "trauma, cerebrovascular" ], "categories": [ { "ref": "MONDO:0004995", "name": "cardiovascular disorder" }, { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "Damage to the blood vessels of the brain" }, "child_count": 0, "reference_id": "MONDO:0005621" }, { "id": 7997, "label": "basal ganglia cerebrovascular disorder", "isLeaf": true, "isRoot": false, "parents": [ 5849, 12183 ], "type_id": 0, "properties": { "xrefs": [ "DOID:10991", "EFO:1000640", "MEDGEN:148381", "MESH:D020144", "UMLS:C0751739" ], "synonyms": [ "cerebrovascular disorder of collection of basal ganglia", "collection of basal ganglia cerebrovascular disorder" ], "categories": [ { "ref": "MONDO:0004995", "name": "cardiovascular disorder" }, { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "A pathological condition caused by impaired blood flow in the basal regions of cerebral hemispheres (basal ganglia), such as infarction; hemorrhage; or ischemia in vessels of this brain region including the lateral lenticulostriate arteries. Primary clinical manifestations include involuntary movements (dyskinesias) and muscle weakness (hemiparesis)." }, "child_count": 0, "reference_id": "MONDO:0006505" }, { "id": 8256, "label": "intracranial arterial disease", "isLeaf": false, "isRoot": false, "parents": [ 12183 ], "type_id": 0, "properties": { "xrefs": [ "DOID:13089", "EFO:1000990", "MEDGEN:199819", "MESH:D020765", "UMLS:C0752138" ], "categories": [ { "ref": "MONDO:0004995", "name": "cardiovascular disorder" }, { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "Pathological conditions involving arteries in the skull, such as arteries supplying the cerebrum, the cerebellum, the brain stem, and associated structures. They include atherosclerotic, congenital, traumatic, infectious, inflammatory, and other pathological processes." }, "child_count": 1, "reference_id": "MONDO:0006808" }, { "id": 8260, "label": "intracranial vasospasm", "isLeaf": true, "isRoot": false, "parents": [ 12183 ], "type_id": 0, "properties": { "xrefs": [ "DOID:13100", "EFO:1000994", "MEDGEN:199760", "MESH:D020301", "UMLS:C0751895" ], "categories": [ { "ref": "MONDO:0004995", "name": "cardiovascular disorder" }, { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "Constriction of arteries in the skull due to sudden, sharp, and often persistent smooth muscle contraction in blood vessels. Intracranial vasospasm results in reduced vessel lumen caliber, restricted blood flow to the brain, and brain ischemia that may lead to hypoxic-ischemic brain injury (hypoxia-ischemia, brain)." }, "child_count": 0, "reference_id": "MONDO:0006812" }, { "id": 8408, "label": "subclavian steal syndrome", "isLeaf": true, "isRoot": false, "parents": [ 4370, 12183 ], "type_id": 0, "properties": { "xrefs": [ "DOID:13002", "ICD9:435.2", "MEDGEN:20983", "MESH:D013349", "MedDRA:10042335", "NCIT:C35044", "SCTID:15258001", "UMLS:C0038531", "icd11.foundation:2123391417" ], "synonyms": [ "subclavian artery stenosis" ], "categories": [ { "ref": "MONDO:0002254", "name": "syndromic disease" }, { "ref": "MONDO:0004995", "name": "cardiovascular disorder" }, { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "An uncommon neurovascular condition seen with exertion of the upper extremity. It is usually caused by atherosclerotic stenosis or occlusion of the subclavian artery proximal to the origin of the vertebral artery. In order to maintain adequate perfusion of the arm during exercise on the affected side, the narrowed subclavian artery siphons off retrograde blood flow from the ipsilateral vertebral artery. This is possible due to lower blood pressure distal to the site of narrowing and collateral circulation through the circle of Willis. Affected individuals may remain asymptomatic until the oxygen demand generated from upper extremity exercise requires a large enough compensatory volume of blood to be diverted from the vertebral artery to provoke vertebrobasilar insufficiency and its accompanying neurological sequelae. Presenting clinical signs may include pain or numbness of the affected arm (with diminished pulses and a brachial systolic blood pressure differential of greater than 20 mmHg as compared to the opposite arm), vertigo, tinnitus, dysarthria, diplopia and syncope. Notably, unlike cerebral infarction, the clinical course does not lead to chronic neurologic disability. Prognosis for recovery of normal anterograde circulation is favorable following endovascular or surgical intervention." }, "child_count": 0, "reference_id": "MONDO:0006983" }, { "id": 10694, "label": "pseudotumor cerebri", "isLeaf": true, "isRoot": false, "parents": [ 8258, 12183 ], "type_id": 0, "properties": { "xrefs": [ "DOID:11459", "EFO:1001132", "GARD:0004561", "ICD10CM:G93.2", "ICD9:348.2", "MEDGEN:18732", "MESH:D011559", "MedDRA:10037149", "NCIT:C85035", "NORD:1294", "OMIM:243200", "Orphanet:238624", "SCTID:68267002", "UMLS:C0033845", "icd11.foundation:815670637" ], "synonyms": [ "IIH", "Idiopathic Intracranial Hypertension", "benign intracran. hypt.", "benign intracranial hypertension", "idiopathic intracranial hypertension", "pseudotumor cerebri", "intracranial hypertension, idiopathic" ], "categories": [ { "ref": "MONDO:0004995", "name": "cardiovascular disorder" }, { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "Idiopathic intracranial hypertension is a neurological disorder characterized by isolated increased intracranial pressure manifesting with recurrent and persistent headaches, nausea, vomiting, progressive and transient obstruction of the visual field, papilledema. Visual loss can be irreversible." }, "child_count": 0, "reference_id": "MONDO:0009468" }, { "id": 18169, "label": "cerebral sinovenous thrombosis", "isLeaf": true, "isRoot": false, "parents": [ 12183 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0021485", "MEDGEN:572643", "Orphanet:329217", "UMLS:C0338573" ], "synonyms": [ "CSVT" ], "categories": [ { "ref": "MONDO:0004995", "name": "cardiovascular disorder" }, { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "A rare but serious cerebrovascular disorder involving thrombosis of the cerebral venous system. It affects children from the newborn period through childhood and adolescence. In childhood CSVT, acute infections of the head and neck such as mastoiditis are most common, followed by chronic underlying diseases such as nephrotic syndrome, cancer, and inflammatory bowel disease. Signs and symptoms are also age related. Seizures and altered mental status are the commonest manifestations in newborns. Headache, vomiting, and lethargy, sometimes with 6th nerve palsy, are the most common symptoms in children and adolescents." }, "child_count": 0, "reference_id": "MONDO:0017993" }, { "id": 18771, "label": "HTRA1-related autosomal dominant cerebral small vessel disease", "isLeaf": true, "isRoot": false, "parents": [ 12183 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0017877", "MEDGEN:1799991", "Orphanet:482077", "UMLS:C5568568" ], "synonyms": [ "HTRA1-related autosomal dominant cerebral angiopathy" ], "categories": [ { "ref": "MONDO:0004995", "name": "cardiovascular disorder" }, { "ref": "MONDO:0005071", "name": "nervous system disorder" } ] }, "child_count": 0, "reference_id": "MONDO:0018832" }, { "id": 19950, "label": "familial porencephaly", "isLeaf": false, "isRoot": false, "parents": [ 12183, 17717, 24270 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0112313", "GARD:0002258", "MEDGEN:401353", "OMIMPS:175780", "Orphanet:99810", "UMLS:C1867983", "icd11.foundation:1833583032" ], "synonyms": [ "hereditary porencephaly", "familial porencephalic white matter disease" ], "categories": [ { "ref": "MONDO:0004995", "name": "cardiovascular disorder" }, { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "An instance of porencephaly that is caused by an inherited modification of the individual's genome." }, "child_count": 21, "reference_id": "MONDO:0020496" }, { "id": 22471, "label": "microangiopathy and leukoencephalopathy, pontine, autosomal dominant", "isLeaf": true, "isRoot": false, "parents": [ 12183, 24270, 25047 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0017855", "MEDGEN:1684781", "OMIM:618564", "Orphanet:477749", "UMLS:C5231411" ], "synonyms": [ "MICROANGIOPATHY AND LEUKOENCEPHALOPATHY, PONTINE, AUTOSOMAL DOMINANT", "PADMAL", "pontine autosomal dominant microangiopathy with leukoencephalopathy", "Dementia, Hereditary Multi-Infarct, Swedish Type" ], "categories": [ { "ref": "MONDO:0004995", "name": "cardiovascular disorder" }, { "ref": "MONDO:0005071", "name": "nervous system disorder" } ] }, "child_count": 0, "reference_id": "MONDO:0032814" }, { "id": 22867, "label": "cathepsin a-related arteriopathy-strokes-leukoencephalopathy", "isLeaf": true, "isRoot": false, "parents": [ 12183, 24270 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0022320", "ICD10CM:I67.8", "MEDGEN:1804103", "Orphanet:575553", "UMLS:C5680354" ], "synonyms": [ "CARASAL" ], "categories": [ { "ref": "MONDO:0004995", "name": "cardiovascular disorder" }, { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "A rare genetic cerebral small vessel disease characterized by an adult-onset primary microangiopathy with severe atherosclerosis of arterioles and secondary leukoencephalopathy. Patients may present with migraine, transient ischemic attacks, stroke with central facial palsy, cognitive dysfunction with impaired concentration, dementia, depression, movement disorder, vertigo, dysphagia, dysarthria, sicca syndrome, impaired REM sleep, and therapy-resistant hypertension, among others. Brain MRI typically shows a leukoencephalopathy that is disproportionately severe and extensive compared to the clinical disease." }, "child_count": 0, "reference_id": "MONDO:0035551" }, { "id": 29229, "label": "precerebral artery stenosis", "isLeaf": true, "isRoot": false, "parents": [ 12183 ], "type_id": 0, "properties": { "xrefs": [ "ICD10CM:I65", "MEDGEN:539068", "SCTID:1055001", "UMLS:C0265089" ], "synonyms": [ "narrowing of precerebral artery" ], "categories": [ { "ref": "MONDO:0004995", "name": "cardiovascular disorder" }, { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "A cerebrovascular disorder characterized by an abnormal narrowing of a precerebral artery." }, "child_count": 0, "reference_id": "MONDO:1030010" }, { "id": 29247, "label": "cerebral artery stenosis", "isLeaf": false, "isRoot": false, "parents": [ 12183 ], "type_id": 0, "properties": { "xrefs": [ "MEDGEN:760198", "UMLS:C1504438" ], "categories": [ { "ref": "MONDO:0004995", "name": "cardiovascular disorder" }, { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "A cerebrovascular disorder characterized by an abnormal narrowing of a cerebral artery." }, "child_count": 1, "reference_id": "MONDO:1040016" }, { "id": 29349, "label": "APP-related brain and vascular amyloidosis", "isLeaf": false, "isRoot": false, "parents": [ 12183, 18631, 21292 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0028185" ], "synonyms": [ "APP-related brain and vascular amyloidosis" ], "categories": [ { "ref": "MONDO:0004995", "name": "cardiovascular disorder" }, { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "A hereditary amyloidosis characterized by a spectrum of neurodegenerative and neurovascular phenotypes caused by pathogenic variant in the APP gene, resulting in an abnormal clearance of amyloid peptides, either by overproduction and decreased clearance of amyloid peptides, with deposition of amyloid in plaques and blood vessel walls. Affected individuals may present with progressive cognitive decline, cerebral vascular amyloidosis with white matter changes, and stroke with or without hemorrhage." }, "child_count": 6, "reference_id": "MONDO:1060190" } ], "roots": [ { "id": 7209, "label": "brain disorder" }, { "id": 23165, "label": "neurovascular disorder" } ] }