{
  "id": 11379,
  "label": "Wernicke-Korsakoff syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0010198",
  "properties": {
    "xrefs": [
      "DOID:10915",
      "EFO:1001242",
      "GARD:0027793",
      "MEDGEN:83883",
      "MESH:C538669",
      "MedDRA:10047913",
      "NCIT:C35764",
      "OMIM:277730",
      "SCTID:69482004",
      "UMLS:C0349464",
      "icd11.foundation:2017611840"
    ],
    "synonyms": [
      "Wernicke-Korsakoff syndrome",
      "Wernicke encephalopathy",
      "alcohol-induced encephalopathy",
      "transketolase defect"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      }
    ],
    "definition": "Wernicke-Korsakoff syndrome is a brain disorder, due to thiamine deficiency that has been associated with both Wernicke's encephalopathy and Korsakoff syndrome. The term refers to two different syndromes, each representing a different stage of the disease. Wernicke's encephalopathy represents the 'acute' phase and Korsakoff's syndrome represents the 'chronic' phase. However, they are used interchangeable in many sites. Wernicke's encephalopathy is characterized by confusion, abnormal stance and gait (ataxia), and abnormal eye movements (nystagmus). Korsakoff's syndrome is observed in a small number of patients. It is a type of dementia, characterized by memory loss and confabulation (filling in of memory gaps with data the patient can readily recall) and involvement of the heart, vascular, and nervous system. Wernicke-Korsakoff syndrome mainly results from chronic alcohol use, but also from dietary deficiencies, prolonged vomiting, eating disorders, systemic diseases (cancer, AIDS, infections), bariatric surgery, transplants, or the effects of chemotherapy. Studies indicate that there may be some genetic predisposition for the disease.Treatment involves supplementing the diet with thiamine. Wernicke encephalopathy is an acute syndrome and requires emergency treatment to prevent death and neurologic complications. In cases where the diagnosis is not confirmed, patients should still be treated while additional evaluations are completed."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 4370,
      "label": "syndromic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:225",
          "MEDGEN:11688",
          "MESH:D013577",
          "NCIT:C28193",
          "OGMS:0000086",
          "UMLS:C0039082"
        ],
        "synonyms": [
          "cluster, symptom",
          "clusters, symptom",
          "symptom cluster",
          "symptom clusters",
          "syndrome",
          "syndrome associated with disease or disorder",
          "syndromes",
          "syndromic disease",
          "syndromic disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "A group of signs, symptoms, and clinicopathological characteristics that may or may not have a genetic basis and collectively define an abnormal condition."
      },
      "child_count": 1182,
      "reference_id": "MONDO:0002254"
    },
    {
      "id": 8312,
      "label": "nutritional deficiency disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6861
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5113",
          "EFO:1001067",
          "ICD10CM:E40-E46",
          "ICD9:269.8",
          "ICD9:269.9",
          "MEDGEN:1677627",
          "MESH:D003677",
          "MedDRA:10046058",
          "NCIT:C3669",
          "SCTID:363246002",
          "SCTID:70241007",
          "UMLS:C4761312"
        ],
        "synonyms": [
          "malnourished",
          "malnutrition"
        ],
        "definition": "A condition produced by dietary or metabolic deficiency. The term includes all diseases caused by an insufficient supply of essential nutrients, i.e., protein (or amino acids), vitamins, and minerals. It also includes an inadequacy of calories. (From Dorland, 27th ed; Stedman, 25th ed)"
      },
      "child_count": 14,
      "reference_id": "MONDO:0006873"
    }
  ],
  "children": [
    {
      "id": 23335,
      "label": "alcohol-induced Wernicke-Korsakoff's syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        11379,
        20731
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027971",
          "MEDGEN:312391",
          "NCIT:C34366",
          "UMLS:C1704427"
        ],
        "synonyms": [
          "alcohol-induced Wernicke-Korsakoff's syndrome",
          "alcohol-induced amnestic syndrome",
          "alcoholic Korsakoff's psychosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "A syndrome which occurs in individuals with a history of alcohol abuse. It is caused by prolonged alcohol-induced neurological damage and malnutrition including vitamin and electrolyte deficiencies. Clinical signs include altered mental status, visual impairment and decreased muscle coordination. The clinical course varies and is, in part, dependent upon the severity of symptoms at presentation. The prognosis is poor and worsens if alcohol abuse continues."
      },
      "child_count": 0,
      "reference_id": "MONDO:0044333"
    }
  ],
  "roots": [
    {
      "id": 4370,
      "label": "syndromic disease"
    },
    {
      "id": 8312,
      "label": "nutritional deficiency disease"
    }
  ]
}