{
  "id": 7417,
  "label": "human T-lymphotropic virus 1 infectious disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005801",
  "properties": {
    "xrefs": [
      "EFO:0007316",
      "GARD:0009645",
      "MEDGEN:6919",
      "MESH:D015490",
      "UMLS:C0020097"
    ],
    "synonyms": [
      "Human T-lymphotropic virus 1 caused disease or disorder",
      "Human T-lymphotropic virus 1 disease or disorder",
      "Human T-lymphotropic virus 1 infectious disease",
      "human T-lymphotropic virus 1 infectious disease",
      "HTLV-1",
      "Human T lymphotropic virus type 1"
    ],
    "definition": "A viral infectious disease that results in increased proliferation of affected CD4 lymphocytes, has material basis in Human T-lymphotropic virus 1, which is transmitted by sexual contact, transmitted by contaminated needles used by intravenous-drug users, and transmitted by breast feeding. The person infected with HTLV-1 eventually develop an often rapidly fatal leukemia, while others will develop a debilitative myelopathy, uveitis, infectious dermatitis, or another inflammatory disorder."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 6834,
      "label": "viral infectious disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7200
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:934",
          "EFO:0000763",
          "ICD9:060-066",
          "ICD9:066.9",
          "ICD9:078.89",
          "ICD9:079.99",
          "MESH:D014777",
          "NCIT:C3439",
          "SCTID:34014006"
        ],
        "synonyms": [
          "Viruses caused disease or disorder",
          "Viruses disease or disorder",
          "Viruses infection",
          "Viruses infectious disease",
          "infection, viral",
          "viral disease",
          "viral disorder",
          "viral infection",
          "infections, Viruses"
        ],
        "definition": "Any disease caused by a virus."
      },
      "child_count": 42,
      "reference_id": "MONDO:0005108"
    }
  ],
  "children": [
    {
      "id": 9363,
      "label": "tropical spastic paraparesis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7417,
        19708
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:321",
          "EFO:0007527",
          "GARD:0008208",
          "ICD10CM:G04.1",
          "ICD9:323.01",
          "MEDGEN:18298",
          "MESH:D015493",
          "MedDRA:10044696",
          "NANDO:1200206",
          "OMIM:159580",
          "Orphanet:289326",
          "SCTID:714279000",
          "UMLS:C0030481",
          "icd11.foundation:1043229589"
        ],
        "synonyms": [
          "HAM/TSP",
          "HTLV-1-associated myelopathy/tropical spastic paraparesis",
          "Human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis",
          "Human T-lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis",
          "TSP",
          "ham/TSP",
          "tropical spastic paraplegia",
          "HTLV-1 associated myelopathy/tropical spastic paraparesis",
          "Human T-cell leukaemia virus type 1 associated myelopathy/tropical spastic paraparesis",
          "Human T-cell leukemia virus type 1 associated myelopathy/tropical spastic paraparesis",
          "familial spastic paraparesis, HTLV-1-associated",
          "ham",
          "myelopathy, HTLV-1-associated",
          "tropical spastic paraparesis (formerly)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Tropical spastic paraparesis is a chronic systemic immune-mediated inflammatory myeloneuropathy, more frequently reported in women than in men, that usually presents in adulthood with slowly progressive spastic paraparesis of the lower limbs, bladder and bowel dysfunction, and sensory disturbances in the lower extremities (e.g. paresthesia and dysesthesia) and that is associated with a human T-cell lymphotropic virus type 1 (HTLV-1) infection."
      },
      "child_count": 0,
      "reference_id": "MONDO:0008039"
    },
    {
      "id": 19296,
      "label": "adult T-cell leukemia/lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5547,
        7179,
        7417,
        16517,
        17658,
        20413
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050523",
          "GARD:0019076",
          "ICD9:204.80",
          "ICDO:9827/3",
          "MEDGEN:44128",
          "MedDRA:10001413",
          "NCIT:C3184",
          "ONCOTREE:ATLL",
          "Orphanet:86875",
          "SCTID:110007008",
          "UMLS:C0023493",
          "icd11.foundation:430573082"
        ],
        "synonyms": [
          "ATLL",
          "T-cell leukaemia of adults",
          "T-cell leukemia of adults",
          "adult T-cell leukaemia",
          "adult T-cell leukemia",
          "adult T-cell leukemia/lymphoma",
          "HTLV-1 associated adult T-cell lymphoma/leukemia",
          "HTLV-I associated adult T-cell leukemia/lymphoma",
          "adult T cell lymphoma/leukemia",
          "adult T-cell leukemia/lymphoma (HTLV-1 positive)",
          "adult T-cell lymphoma",
          "adult T-cell lymphoma/leukemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A peripheral (mature) T-cell neoplasm linked to the human T-cell leukemia virus type 1 (HTLV-1), adult T-cell leukemia/lymphoma is endemic in several regions of the world, in particular Japan, the Caribbean, and parts of Central Africa."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019471"
    }
  ],
  "roots": [
    {
      "id": 6834,
      "label": "viral infectious disease"
    }
  ]
}