{
  "id": 4674,
  "label": "pediatric osteosarcoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002623",
  "properties": {
    "xrefs": [
      "DOID:3361",
      "MEDGEN:272464",
      "NANDO:2200048",
      "NCIT:C6585",
      "UMLS:C1332986"
    ],
    "synonyms": [
      "osteosarcoma",
      "childhood osteogenic sarcoma",
      "childhood osteosarcoma",
      "childhood osteosarcoma (disease)",
      "osteosarcoma (disease) of childhood",
      "paediatric osteosarcoma (disease)",
      "pediatric osteosarcoma",
      "pediatric osteosarcoma (disease)"
    ],
    "definition": "An osteosarcoma occurring in childhood."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 8005,
      "label": "childhood malignant neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        20320
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000654",
          "MEDGEN:82962",
          "NCIT:C4005",
          "UMLS:C0278704"
        ],
        "synonyms": [
          "childhood cancer",
          "childhood malignant neoplasm",
          "childhood neoplasm, malignant",
          "malignant childhood neoplasm",
          "malignant childhood tumor",
          "malignant childhood tumour",
          "malignant paediatric neoplasm",
          "malignant paediatric tumour",
          "malignant pediatric neoplasm",
          "malignant pediatric tumor",
          "paediatric cancer",
          "pediatric cancer",
          "malignant neoplasm"
        ],
        "definition": "A malignant tumor that occurs in children. Representative examples include soft tissue and bone sarcomas (e.g. osteosarcoma) and embryonal neoplasms (e.g. hepatoblastoma and rhabdoid tumor)."
      },
      "child_count": 60,
      "reference_id": "MONDO:0006517"
    },
    {
      "id": 11016,
      "label": "osteosarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6816
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3347",
          "EFO:0000637",
          "HP:0002669",
          "ICDO:9180/3",
          "MEDGEN:10501",
          "MESH:D012516",
          "NANDO:2200048",
          "NCIT:C9145",
          "ONCOTREE:OS",
          "UMLS:C0029463"
        ],
        "synonyms": [
          "bone tissue neoplasm",
          "osteogenic sarcoma",
          "osteoid sarcoma",
          "osteosarcoma",
          "osteosarcoma (disease)",
          "osteosarcoma, malignant",
          "sarcoma of osteoid"
        ],
        "definition": "A usually aggressive malignant bone-forming mesenchymal neoplasm, predominantly affecting adolescents and young adults. It usually involves bones and less frequently extraosseous sites. It often involves the long bones (particularly distal femur, proximal tibia, and proximal humerus). Pain with or without a palpable mass is the most frequent clinical symptom. It may spread to other anatomic sites, particularly the lungs."
      },
      "child_count": 6,
      "reference_id": "MONDO:0009807"
    }
  ],
  "children": [
    {
      "id": 5542,
      "label": "childhood parosteal osteosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4674,
        8265
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5809",
          "GARD:0023604",
          "MEDGEN:272467",
          "NCIT:C6589",
          "UMLS:C1332994"
        ],
        "synonyms": [
          "childhood parosteal osteogenic sarcoma",
          "childhood parosteal osteosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A low grade malignant bone-forming mesenchymal neoplasm arising from the surface of the bone. It occurs in childhood and usually affects the distal posterior femur, the proximal tibia, and proximal humerus. Painless swelling is the usual clinical sign. The prognosis is usually excellent."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003654"
    },
    {
      "id": 5999,
      "label": "childhood extraosseous osteosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4672,
        4674
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7297",
          "GARD:0023863",
          "MEDGEN:232060",
          "NCIT:C27376",
          "UMLS:C1332968"
        ],
        "synonyms": [
          "childhood extraosseous osteosarcoma",
          "childhood extraskeletal osteosarcoma",
          "extraosseous osteosarcoma of childhood",
          "paediatric extraosseous osteosarcoma",
          "paediatric extraskeletal osteosarcoma",
          "pediatric extraosseous osteosarcoma",
          "pediatric extraskeletal osteosarcoma"
        ],
        "definition": "An osteosarcoma arising from the soft tissue, and occurring during childhood."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004176"
    },
    {
      "id": 6122,
      "label": "childhood intracortical osteosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4674,
        4682
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7612",
          "GARD:0023922",
          "MEDGEN:232350",
          "NCIT:C6590",
          "UMLS:C1332974"
        ],
        "synonyms": [
          "childhood conventional osteosarcoma",
          "childhood intracortical osteosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A high grade malignant bone-forming mesenchymal neoplasm that produces osteoid and occurs in childhood. It arises from the medullary portion of the bone. It affects the long bones, and most commonly, the distal femur, proximal tibia, and proximal humerus. Pain with or without a palpable mass is the most common clinical presentation. It usually has an aggressive growth and may metastasize through the hematogenous route. The lung is the most frequent site of metastasis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004306"
    }
  ],
  "roots": [
    {
      "id": 8005,
      "label": "childhood malignant neoplasm"
    },
    {
      "id": 11016,
      "label": "osteosarcoma"
    }
  ]
}