{
  "id": 4347,
  "label": "ovarian epithelial tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002229",
  "properties": {
    "xrefs": [
      "DOID:2152",
      "ICD9:239.5",
      "MEDGEN:90969",
      "NCIT:C4381",
      "ONCOTREE:OVT",
      "SCTID:237057005",
      "UMLS:C0341823"
    ],
    "synonyms": [
      "epithelial neoplasm of ovary",
      "epithelial neoplasm of the ovary",
      "epithelial tumor of ovary",
      "epithelial tumor of the ovary",
      "epithelial tumour of ovary",
      "epithelial tumour of the ovary",
      "ovarian epithelial tumor",
      "ovarian surface epithelial-stromal tumor",
      "ovarian surface epithelial-stromal tumour",
      "ovarian surface-epithelial stromal neoplasm",
      "ovary epithelial neoplasm",
      "OVT",
      "ovary epithelial cancer"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A benign, borderline, or malignant tumor that originates from the surface epithelium of the ovary. It is composed of epithelial cells and stroma. Representative examples of benign tumors include serous cystadenoma, mucinous cystadenoma, and benign Brenner tumor. Representative examples of borderline tumors include serous surface papillary tumor, mucinous adenofibroma, and borderline Brenner tumor. Representative examples of malignant tumors include serous adenocarcinoma, mucinous adenocarcinoma, endometrioid adenocarcinoma, and malignant Brenner tumor."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 11,
  "parents": [
    {
      "id": 7265,
      "label": "epithelial neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0006858",
          "MEDGEN:277963",
          "MESH:D009375",
          "NCIT:C3709",
          "SCTID:118285006",
          "UMLS:C1368683"
        ],
        "synonyms": [
          "epithelial neoplasm",
          "epithelioma"
        ],
        "definition": "A benign or malignant neoplasm that arises from and is composed of epithelial cells. This category include adenomas, papillomas, and carcinomas."
      },
      "child_count": 24,
      "reference_id": "MONDO:0005626"
    },
    {
      "id": 20309,
      "label": "ovarian neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7207,
        20384
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0003893",
          "ICD9:239.5",
          "MEDGEN:181539",
          "NCIT:C4984",
          "SCTID:123843001",
          "UMLS:C0919267"
        ],
        "synonyms": [
          "neoplasm of ovary",
          "neoplasm of the ovary",
          "ovarian neoplasm",
          "ovarian tumor",
          "ovarian tumors",
          "ovarian tumour",
          "ovarian tumours",
          "ovary neoplasm",
          "ovary neoplasm (disease)",
          "ovary tumor",
          "ovary tumour",
          "tumor of ovary",
          "tumor of the ovary",
          "tumour of ovary",
          "tumour of the ovary"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign, borderline, or malignant neoplasm involving the ovary."
      },
      "child_count": 16,
      "reference_id": "MONDO:0021068"
    }
  ],
  "children": [
    {
      "id": 4468,
      "label": "ovarian Brenner tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4347,
        21291
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2636",
          "GARD:0009397",
          "MEDGEN:1716777",
          "NCIT:C3872",
          "SCTID:254859006",
          "UMLS:C5234884"
        ],
        "synonyms": [
          "Brenner tumor",
          "Brenner tumour",
          "Brenner neoplasm of ovary",
          "Brenner neoplasm of the ovary",
          "Brenner tumor of ovary",
          "Brenner tumor of the ovary",
          "Brenner tumour of ovary",
          "Brenner tumour of the ovary",
          "ovarian Brenner neoplasm",
          "ovarian Brenner tumor",
          "ovary Brenner tumor",
          "ovary Brenner tumour",
          "benign ovarian Brenner tumor",
          "benign ovarian Brenner tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign, borderline, or malignant transitional cell neoplasm arising from the ovary. It constitutes between 1% and 2% of all ovarian neoplasms. The average age at presentation is about 50 years. Grossly it is usually unilateral, firm and white or yellowish. Microscopically it consists of solid and cystic nests of epithelial cells resembling transitional epithelium surrounded by an abundant stromal component of dense, fibroblastic nature."
      },
      "child_count": 2,
      "reference_id": "MONDO:0002370"
    },
    {
      "id": 5411,
      "label": "ovarian squamous cell neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4347,
        4600
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5532",
          "NCIT:C40092"
        ],
        "synonyms": [
          "ovarian squamous cell neoplasm",
          "ovarian squamous cell tumor",
          "ovarian squamous cell tumour",
          "ovary squamous cell neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A squamous cell tumor that arises from the ovary and is not associated with a germ cell tumor."
      },
      "child_count": 2,
      "reference_id": "MONDO:0003495"
    },
    {
      "id": 5636,
      "label": "ovarian mucinous neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4347
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6067",
          "MEDGEN:235419",
          "NCIT:C5242",
          "UMLS:C1335168"
        ],
        "synonyms": [
          "mucinous neoplasm of ovary",
          "mucinous neoplasm of the ovary",
          "mucinous tumor of ovary",
          "mucinous tumor of the ovary",
          "mucinous tumour of ovary",
          "mucinous tumour of the ovary",
          "ovarian mucinous neoplasm",
          "ovarian mucinous tumor",
          "ovarian mucinous tumour",
          "malignant ovarian mucinous neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign, borderline, or malignant epithelial tumor of the ovary characterized by the presence of neoplastic epithelial cells that contain intracytoplasmic mucin and may resemble the epithelial cells of the endocervix or gastrointestinal tract."
      },
      "child_count": 2,
      "reference_id": "MONDO:0003756"
    },
    {
      "id": 5684,
      "label": "ovarian seromucinous tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4347,
        20288
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6211",
          "MEDGEN:83409",
          "NCIT:C4508",
          "SCTID:254855000",
          "UMLS:C0346166"
        ],
        "synonyms": [
          "mixed epithelial neoplasm of ovary",
          "mixed epithelial neoplasm of the ovary",
          "mixed epithelial tumor of the ovary",
          "mixed epithelial tumour of the ovary",
          "ovarian Seromucinous tumor",
          "ovarian Seromucinous tumour",
          "ovarian mixed epithelial neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign, borderline, or malignant mixed epithelial tumor of the ovary. It is characterized by the presence of more than one epithelial cell type, most often serous and endocervical-type mucinous."
      },
      "child_count": 2,
      "reference_id": "MONDO:0003811"
    },
    {
      "id": 5686,
      "label": "ovarian papillary tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4347,
        20336
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6214",
          "MEDGEN:99195",
          "NCIT:C8430",
          "UMLS:C0476121"
        ],
        "synonyms": [
          "ovarian papillary neoplasm",
          "ovarian papillary tumor",
          "ovarian papillary tumor (morphologic abnormality)",
          "ovarian papillary tumour (morphologic abnormality)",
          "papillary neoplasm of ovary",
          "papillary neoplasm of the ovary",
          "papillary tumor of ovary",
          "papillary tumor of the ovary",
          "papillary tumour of ovary",
          "papillary tumour of the ovary"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign, borderline, or malignant epithelial tumor that arises from the ovary and is characterized by the presence of papillary proliferations. Representative examples include surface papilloma, borderline serous surface papillary tumor, and serous surface papillary adenocarcinoma."
      },
      "child_count": 6,
      "reference_id": "MONDO:0003813"
    },
    {
      "id": 5749,
      "label": "ovarian mucinous adenofibroma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3047,
        4347,
        4488
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6469",
          "MEDGEN:309511",
          "NCIT:C40040",
          "UMLS:C1518723"
        ],
        "synonyms": [
          "mucinous adenofibroma of ovary",
          "ovarian mucinous adenofibroma",
          "ovary mucinous adenofibroma"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign neoplasm of the ovary characterized by the presence of glands with mucinous columnar epithelial cells in a fibrotic stroma."
      },
      "child_count": 3,
      "reference_id": "MONDO:0003887"
    },
    {
      "id": 6900,
      "label": "ovarian adenoma benign",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3047,
        4347,
        6714,
        22952
      ],
      "type_id": 0,
      "properties": {
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign adenoma of ovary"
      },
      "child_count": 8,
      "reference_id": "MONDO:0005179"
    },
    {
      "id": 16720,
      "label": "borderline epithelial tumor of ovary",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4347
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000140",
          "GARD:0009363",
          "MEDGEN:777110",
          "NCIT:C4783",
          "Orphanet:206473",
          "SCTID:764791008",
          "UMLS:C3665489"
        ],
        "synonyms": [
          "borderline epithelial neoplasm of ovary",
          "borderline epithelial neoplasm of the ovary",
          "borderline epithelial tumor of ovary",
          "borderline epithelial tumor of the ovary",
          "borderline epithelial tumour of the ovary",
          "borderline ovarian epithelial neoplasm",
          "borderline ovarian epithelial tumor",
          "borderline ovarian epithelial tumour",
          "borderline ovarian surface epithelial-stromal tumor",
          "borderline ovarian surface epithelial-stromal tumour",
          "epithelial neoplasm of ovary of borderline malignancy",
          "epithelial neoplasm of the ovary of borderline malignancy",
          "epithelial ovarian neoplasm of borderline malignancy",
          "epithelial ovarian tumor of borderline malignancy",
          "epithelial ovarian tumour of borderline malignancy",
          "epithelial tumor of ovary of borderline malignancy",
          "epithelial tumor of the ovary of borderline malignancy",
          "epithelial tumour of ovary of borderline malignancy",
          "epithelial tumour of the ovary of borderline malignancy",
          "low malignant potential ovarian tumor",
          "low malignant potential ovarian tumour",
          "ovarian borderline malignant tumor",
          "ovarian borderline malignant tumour",
          "ovarian low malignant potential tumor",
          "ovarian low malignant potential tumour",
          "ovarian tum. of low malig. poten.",
          "ovarian tumor of low malignant potential",
          "ovarian tumors of low malignant potential",
          "ovarian tumour of low malignant potential",
          "ovarian tumours of low malignant potential"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A low grade epithelial tumor arising from the ovary. It is characterized by an atypical proliferation of epithelial cells. There is no evidence of stromal invasion."
      },
      "child_count": 1,
      "reference_id": "MONDO:0016093"
    },
    {
      "id": 18447,
      "label": "malignant epithelial tumor of ovary",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4347,
        6734,
        9481
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2151",
          "GARD:0009362",
          "MEDGEN:577291",
          "MESH:C538090",
          "NCIT:C40026",
          "Orphanet:398934",
          "SCTID:254849005",
          "UMLS:C0346161"
        ],
        "synonyms": [
          "epithelial cancer of ovary",
          "malignant ovarian epithelial tumor",
          "malignant ovarian epithelial tumour",
          "malignant ovarian surface epithelial-stromal neoplasm",
          "malignant ovarian surface epithelial-stromal tumor",
          "malignant ovarian surface epithelial-stromal tumour",
          "ovarian epithelial cancer",
          "ovarian epithelial tumor, malignant",
          "ovarian malignant epithelial tumor",
          "ovarian malignant epithelial tumour",
          "ovarian stromal cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An invasive malignant tumor that originates from the surface epithelium of the ovary. It is composed of malignant epithelial cells and stroma. Representative examples include serous adenocarcinoma, mucinous adenocarcinoma, endometrioid adenocarcinoma, clear cell adenocarcinoma, and malignant Brenner tumor."
      },
      "child_count": 18,
      "reference_id": "MONDO:0018364"
    },
    {
      "id": 20381,
      "label": "ovarian clear cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4347
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:138040",
          "NCIT:C40076",
          "ONCOTREE:CCOV",
          "UMLS:C0346164"
        ],
        "synonyms": [
          "ovarian clear cell neoplasm",
          "ovarian clear cell tumor",
          "clear cell ovarian cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign, borderline, or malignant epithelial tumor of the ovary that is characterized by a predominance of clear and hobnail cells."
      },
      "child_count": 1,
      "reference_id": "MONDO:0021144"
    },
    {
      "id": 22963,
      "label": "ovarian serous tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4347,
        22964
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:141653",
          "NCIT:C8431",
          "UMLS:C0476122"
        ],
        "synonyms": [
          "ovarian serous neoplasm",
          "ovarian serous tumor",
          "serous neoplasm of ovary",
          "serous neoplasm of the ovary",
          "serous tumor of ovary",
          "serous tumor of the ovary",
          "serous tumour of ovary",
          "serous tumour of the ovary"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign, borderline, or malignant epithelial tumor of the ovary characterized by the presence of neoplastic epithelial cells that, in well differentiated tumors, resemble the epithelial cells of the fallopian tube and, in poorly differentiated tumors, show anaplastic features. Approximately thirty to fifty percent of the tumors are bilateral. Grossly, the better differentiated tumors consist of cystic masses, usually unilocular, containing a clear but sometimes viscous fluid. Papillary formations are often present. The more malignant tumors tend to be solid and invasive, with areas of necrosis and hemorrhage."
      },
      "child_count": 4,
      "reference_id": "MONDO:0037255"
    }
  ],
  "roots": [
    {
      "id": 7265,
      "label": "epithelial neoplasm"
    },
    {
      "id": 20309,
      "label": "ovarian neoplasm"
    }
  ]
}